| 货号 | 1961/50 |
| 别名 | 4-Iodo-N-[4-methoxy-3-(4-methyl-1-p |
| 供应商 | Tocris |
| 生物活性 | Potent and selective 5-HT6 receptor antagonist (pKi = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 523.82 |
| 分子式 | C18H22IN3O3S.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 50 mM in DMSO |
| CAS号 | 209480-63-7 |
| 参考文献 | Eastet al (2002) 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585. Synapse 45 191. PMID: 12112397. Hirstet al (2000) Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue. Br.J.Pharmacol. 130 1597. PMID: 10928963. Bromidgeet al (1999) 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J.Med.Chem. 42 202. PMID: 9925723. |