| 货号 | 1372/50 |
| 别名 | N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-m |
| 供应商 | Tocris |
| 生物活性 | Potent and selective 5-HT2B receptor antagonist (pA2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT2C(pKi = 5.82), 5-HT2A(pKi < 5.2), 5-HT1A,1D,1E, 5-HT3 and 5-HT4receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 286.35 |
| 分子式 | C14H14N4OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| CAS号 | 152239-46-8 |
| 参考文献 | Ebrahimkhaniet al (2011) Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease. Nat.Med. 17 1668. PMID: 22120177. Glusa and Pertz (2000) Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors. Br.J.Pharmacol. 130 692. PMID: 10821800. Bonhauset al (1995) The pharmacology and distribution of human 5-hydroxytryptamine2B(5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br.J.Pharmacol. 115 622. PMID: 7582481. Forbeset al(1995)N-(1-Methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist. J.Med.Chem. 38 855. PMID: 7699699. |