| 货号 | 3739/50 |
| 别名 | Succinic acid mono-(1-dimethylaminomethyl-2-(2-[2 |
| 供应商 | Tocris |
| 生物活性 | Selective 5-HT2A receptor antagonist (pKi values are 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Displays selectivity over 5-HT1, 5-HT3, 5-HT4H1, H2, M3,α1-adrenergic,α2-adrenergic and β-adrenergic receptors. Displays cardioprotective activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 465.97 |
| 分子式 | C24H31NO6.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| CAS号 | 135159-51-2 |
| 参考文献 | Nishiyama (2009) Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats. Eur.J.Pharmacol. 614 122. PMID: 19318092. Rashidet al (2003) Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling. Life Sci. 73 193. PMID: 12738034. Brasilet al (2002) Blockade of 5-HT(2A) receptors by sarpogrelate protects the heart against myocardial infarction in rats. J.Cardiovasc.Pharmacol.Ther. 7 53. PMID: 12000979. |