| 货号 | 5138/50 |
| 别名 | 2-[[4-(Diethylamino)-2-hydroxypheny |
| 供应商 | Tocris |
| 生物活性 | AMP-activated protein kinase (AMPK) activator (EC50 = 1 μM); activates AMPK indirectly through a CaMKKβ-dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC50 = 0.5 μM). Induces autophagy and promotes Aβdegradationin vitro. Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 312.37 |
| 分子式 | C17H20N4O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 5 mM in ethanol |
| 参考文献 | Capirallaet al (2012) Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages. FASEB J. 279 3791. PMID: 22909341. Vingtdeuxet al (2011) Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid- |