| 货号 | 1050/50 |
| 别名 | 8-[5-(2,4-Dimethoxy-5-(4-trifluorom |
| 供应商 | Tocris |
| 生物活性 | Potent and selective 5-HT2C antagonist (pKi = 8.7). Displays ~ 100-fold selectivity over the 5-HT2A and 5-HT2B subtypes and is > 100-fold selective over other 5-HT receptors, α- and β-adrenergic and muscarinic ACh receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 649.08 |
| 分子式 | C27H31F3N4O7S.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 185376-97-0 |
| 参考文献 | Bonhauset al (1998) Absorption and brain penetration of a high affinity, highly selective 5-HT2C receptor antagonist, RS-102221. Ann.N.Y.Acad.Sci. 861 269. PMID: 9928284. Bonhauset al (1997) RS-102221: a novel high affinity and selective 5-HT2C receptor antagonist. Neuropharmacology 36 621. PMID: 9225287. Weinhardtet al (1996) Some benzenesulphonamido-substituted valerophenones that are selective antagonists for the 5-HT2C receptor. Bioorg.Med.Chem.Lett. 62687. |