| 货号 | 1594/50 |
| 别名 | (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50values are 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivoandin vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 455.55 |
| 分子式 | C22H29NO2.C4H4O4 |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO |
| CAS号 | 169274-78-6 |
| 参考文献 | Kosowski and Liljequist (2004) The NR2B- selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(±)-(R*,S*)-α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus accumbens. J.Pharmacol.Exp.Ther. 311 560. PMID: 15256539. Lynchet al (2001) Pharmacological characterization of interactions of RO 25-6981 with the NR2B (ε2) subunit. Eur.J.Pharmacol. 416 185. PMID: 11290368. Fischeret al (1997) Ro 25-6981, a highly potent and selective blocker of N-Methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J.Pharmacol.Exp.Ther. 283 1285. PMID: 9400004. |