| 货号 | 1622/50 |
| 别名 | 2-Amino-N-(1-methyl-1,2-diphenyleth |
| 供应商 | Tocris |
| 生物活性 | Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC50 = 8 - 68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na+ channels (IC50 = 161 mM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 304.82 |
| 分子式 | C17H20N2O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 111686-79-4 |
| 参考文献 | Santangeliet al (2002) Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur.J.Pharmacol. 438 63. PMID: 11906711. Subramaniamet al (1996) Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite. J.Pharmacol.Exp.Ther. 276 161. PMID: 8558426. Palmeret al (1995) Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann.N.Y.Acad.Sci. 765 236. PMID: 7486610. |