| 货号 | 4396/50 |
| 别名 | 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5- |
| 供应商 | Tocris |
| 生物活性 | Induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 317.34 |
| 分子式 | C17H19NO5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Golovineet al (2012) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate [Epub ahead of print]. PMID: 22592999. Rajet al (2011) Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475 231. PMID: 21753854. |