| 货号 | 3943/50 |
| 别名 | N-Methyl-N-[2-[[4-(1-Methylethyl)ph |
| 供应商 | Tocris |
| 生物活性 | Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. Corrects gating defects of CFTR mutants such as ΔF508 (Ka = 0.3 μM), E193K and G970R (Kd values are 0.22 μM and 0.45 μM respectively). Increases ΔF508-CFTR Cl- currents in the presence of forskolin; displays no effect on Ca2+-activated Cl-current. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 439.55 |
| 分子式 | C28H29N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 853138-65-5 |
| 参考文献 | Pedemonteet al (2010) Influence of cell background on pharmacological rescue of mutant CFTR. Am.J.Physiol.Cell Physiol 298 C866. PMID: 20053923. Caputoet al (2009) Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators. J.Pharmacol.Exp.Ther. 330 783. PMID: 19491324. Pedemonteet al (2005) Phenylglycine and sulphonamide correctors of defective DF508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol.Pharmacol. 67 1797. PMID: 15722457. |