| 货号 | 5716/50 |
| 别名 | 3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3 |
| 供应商 | Tocris |
| 生物活性 | Potent LRRK2 inhibitor (IC50 = 3 nM). Attenuates α-synuclein-induced dopaminergic neurodegeneration and neuroinflammation in G2019S-LRRK2 expressing rats. Also neuroprotective in wild type rats. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 305.33 |
| 分子式 | C17H15N5O |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Daheret al (2015) Leucine-rich repeat kinase 2 (LRRK2) pharmacological inhibition abates α-synuclein gene-induced neurodegeneration. J.Biol.Chem. 290 19433. PMID: 26078453. Hendersonet al (2015) Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J.Med.Chem. 58 419. PMID: 25353650. |