| 货号 | 2606/50 |
| 别名 | 1,2,3,6-Tetrahydro-5-[3-(4-methylph |
| 供应商 | Tocris |
| 生物活性 | High affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1andσ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 372.42 |
| 分子式 | C18H22N2O.C2H2O4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 154130-99-1 |
| 参考文献 | Leveret al (2014) Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaines motor stimulatory effects in mice by PD144418. J.Pharmacol.Exp.Ther. 351 153. PMID: 25100754. Akunneet al (1997) The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 36 51. PMID: 9144641. |