| 货号 | 2830/50 |
| 别名 | 2-[[4-[2-(3,4-Dichlorophenyl)ethyl] |
| 供应商 | Tocris |
| 生物活性 | Human ether-a-go-go (hERG) KV11.1 potassium channel activator. Displays no major effect on INa, ICa/L, IK1 and IKs currents. Causes resting membrane hyperpolarization and decreases action potential duration in rat myocytes in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 386.27 |
| 分子式 | C21H17Cl2NO2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| CAS号 | 313674-97-4 |
| 参考文献 | Duff (2008) hERG: The long and short of it. Heart Rhythm 5 591. PMID: 18362028. Yeung and Greenwood (2007) Pharmacological and biophysical isolation of K+ currents encoded by ether-a-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am.J.Physiol.Cell.Physiol. 292 C468. PMID: 16870833. Zhouet al (2005) Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. Mol.Pharmacol. 68 876. PMID: 15976038. |