| 货号 | 4643/50 |
| 别名 | N-Hydroxy-1-[(4-methoxyphenyl)methy |
| 供应商 | Tocris |
| 生物活性 | Potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 296.32 |
| 分子式 | C17H16N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH |
| 参考文献 | Pipaliaet al (2011) Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proc.Natl.Acad.Sci.U.S.A. 108 5620. PMID: 21436030. Balasubramanianet al (2008) A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 22 1026. PMID: 18256683. |