| 货号 | 4733/50 |
| 别名 | 1-[5-[(2,3-Dichlorophenyl)thio]-4-n |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 348.22 |
| 分子式 | C12H7Cl2NO3< |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Chauhanet al (2012) A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell. 22 345. PMID: 22975377. Weinstocket al (2012) Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. J.Med.Chem. 3789. |