| 货号 | 2936/50 |
| 别名 | 2-Methyl-7-[Phenyl(phenylamino)meth |
| 供应商 | Tocris |
| 生物活性 | Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 340.42 |
| 分子式 | C23H20N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 6964-62-1 |
| 参考文献 | Shangary and Shaomeng (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol. 49223. Luet al (2006) Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem. 49 3759. PMID: 16789731. |