| 货号 | 3034/50 |
| 别名 | 4,4'-diacetyldiphenylureabis(guanylhydrazone) ditosylate; DDUG |
| 供应商 | Tocris |
| 生物活性 | Selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 752.86 |
| 分子式 | C19H24N10O.2C7H8O3S |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 15427-93-7 |
| 参考文献 | Jobsonet al (2007) Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol.Pharmacol. 72 876. PMID: 17616632. Byczkowskiet al (1982) Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Cancer Res. 42 3592. PMID: 6896674. Byczkowskiet al (1981) Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. Biochem.Pharmacol. 30 2851. PMID: 6895596. |