| 货号 | 3439/50 |
| 别名 | 1-Hexadecyl-2-methyl-3-(phenylmethy |
| 供应商 | Tocris |
| 生物活性 | Eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC50 values are 0.7 - 4.8 μM) and blocks G1/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro(IC50 = 6.6 μM) and in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 524.56 |
| 分子式 | C27H45IN2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 75 mM in ethanol |
| CAS号 | 278603-08-0 |
| 参考文献 | Chen (2011) 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 286 43951. PMID: 22020937. Aroraet al (2004) P-glycoprotein mediates resistance to histidine kinase inhibitors. Mol.Pharmacol. 66 460. PMID: 15322237. Aroraet al (2003) Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 63 6894. PMID: 14583488. Yamamotoet al (2001) Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis. Biosci.Biotechnol.Biochem. 65 2306. PMID: 11758928. |