| 货号 | 2456/50 |
| 别名 | 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4 |
| 供应商 | Tocris |
| 生物活性 | Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50 values are 0.043, > 100 and > 100 μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effects in vivoandin vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 377.91 |
| 分子式 | C21H27NO3.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
| CAS号 | 193359-26-1 |
| 参考文献 | Higginset al (2003) Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition. Neuropharmacology 44 324. PMID: 12604092. Gillet al (2002) Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist. J.Pharmacol.Exp.Ther. 302 940. PMID: 12183650. Zhouet al (1999) 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J.Med.Chem. 42 2993. PMID: 10425109. |