| 货号 | 2186/50 |
| 别名 | 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-b |
| 供应商 | Tocris |
| 生物活性 | Non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 349.4 |
| 分子式 | C22H20FNO2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 41179-33-3 |
| 参考文献 | Gurgiset al (2015) Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discovery 115028. Davidsonet al (2004) Discovery and characterisation of a substrate selective p38α inhibitor. Biochemistry 43 11658. PMID: 15362850. |