| 货号 | 0752/50 |
| 别名 | N-(4-Chlorobenzyl)-S-[3-(4(5)-imida |
| 供应商 | Tocris |
| 生物活性 | An extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM. Also available as part of the Histamine H3 Receptor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 470.65 |
| 分子式 | C14H17ClN4S.2HBr |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 145231-45-4 |
| 参考文献 | Bucklandet al (2003) Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor. Br.J.Pharmacol. 140 1117. PMID: 14530216. Liuet al (2001) Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. Mol. Pharmacol. 59 420. PMID: 11179434. Yokoyamaet al (1994) Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice. Eur.J.Pharmacol. 260 23. PMID: 7957622. Van der Gootet al (1992) Isothiourea analogues of histamine as potent agonists or antagonists of the histamine H3 receptor. Eur.J.Med.Chem. 27511. |