| 货号 | 3235/50 |
| 别名 | 3-Cyano-N-(1,3-diphenyl-1H-pyrazol- |
| 供应商 | Tocris |
| 生物活性 | Brain penetrant, selective positive allosteric modulator at the mGlu5 receptor (EC50 values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 364.4 |
| 分子式 | C23H16N4O |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO |
| CAS号 | 781652-57-1 |
| 参考文献 | Chenet al (2007) Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol.Pharmacol. 71 1389. PMID: 17303702. Kinneyet al (2005) A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rats behavioral models. J.Pharmacol.Exp.Ther. 313 199. PMID: 15608073. Lindsleyet al (2004) Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J.Med.Chem. 47 5825. PMID: 15537338. |