| 货号 | 3949/50 |
| 别名 | N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3 |
| 供应商 | Tocris |
| 生物活性 | Selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 413.92 |
| 分子式 | C21H19N3O2S.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 856702-40-4 |
| 参考文献 | Fellet al (2010) Activation of metabotropic glutamate receptors (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge. Neuropharmacology. 58 632. PMID: 19951716. Johnsonet al (2005) Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology. 179 271. PMID: 15717213. |