| 货号 | 3966/50 |
| 别名 | N-[(4-Methoxyphenyl)methyl]-N'-(5-ni |
| 供应商 | Tocris |
| 生物活性 | Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 308.31 |
| 分子式 | C12H12N4O4S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 487021-52-3 |
| 参考文献 | Gouldet al (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 7 387. PMID: 15315719. Bhatet al (2003) Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 278 45937. PMID: 12928438. Bhat and Budd (2002) GSK3β signalling: casting a wide net in Alzheimer's disease. Neurosignals 11 251. PMID: 12566926. |