| 货号 | 0904/50 |
| 别名 | (RS)-1-Aminoindan-1,5-dicarboxylic acid; UPF 523 |
| 供应商 | Tocris |
| 生物活性 | A relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 221.21 |
| 分子式 | C11H11NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in 1.1eq. NaOH |
| CAS号 | 168560-79-0 |
| 参考文献 | Moroniet al (1997) Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. J.Pharmacol.Exp.Ther. 281 721. PMID: 9152378. Nielsenet al (1997) Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur.J.Pharmacol. 326 105. PMID: 9196260. Pellicciariet al (1995) 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J.Med.Chem. 38 3717. PMID: 7562903. |