| 货号 | 4473/50 |
| 别名 | N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5- |
| 供应商 | Tocris |
| 生物活性 | Potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). Selective for P2X7 receptors (IC50 >5-10μM for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app = 2.4 nM for rat P2X7receptors). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 315.37 |
| 分子式 | C19H17N5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Ableet al (2011) Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat. Br.J.Pharmacol. 162 405. PMID: 20840537. Donnelly-Robertset al (2009) [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology 56 223. PMID: 18602931. |