| 货号 | 3701/50 |
| 别名 | N-[1-[[(Cyanoamino)(5-quinolinylami |
| 供应商 | Tocris |
| 生物活性 | Potent and selective P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 474.55 |
| 分子式 | C26H30N6O3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| CAS号 | 861393-28-4 |
| 参考文献 | Amorosoet al (2015) The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma. Oncogene 34 5240. PMID: 25619831. Donnelly-Robertset al (2009) Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br.J.Pharmacol. 157 1203. PMID: 19558545. King (2007) Novel P2X7 receptor antagonists ease the pain. Br.J.Pharmacol. 151 565. PMID: 17471176. Honoreet al (2006) A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J.Pharmacol.Exp.Ther. 319 1376. PMID: 16982702. |