| 货号 | 1052/50 |
| 别名 | N-[5-(4,5-Dihydro-1H-imidazol-2-yl) |
| 供应商 | Tocris |
| 生物活性 | Potentα-adrenoceptor agonist that is at least 35-fold more potent at α1A than at α1Borα1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro(EC50 = 6.9 nmol/L). Also available as part of the α1-Adrenoceptor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 390.29 |
| 分子式 | C14H19N3O3S.HBr |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| CAS号 | 107756-30-9 |
| 参考文献 | Luoet al (2007) Receptor subtype involved in α1A-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta.Pharmacol.Sin. 28 968. PMID: 17588332. Meyeret al (1996) Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α1A receptor agonist. J.Med.Chem. 39 4116. PMID: 8831777. Knepperet al (1995) A-61603, a potent α1-adrenergic receptor agonist, selective for the α1A receptor subtype. J.Pharmacol.Exp.Ther. 274 97. PMID: 7616455. |