| 货号 | 2972/50 |
| 别名 | 3-[[5-(2,3-Dichlorophenyl)-1H-tetra |
| 供应商 | Tocris |
| 生物活性 | Competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 342.61 |
| 分子式 | C13H9Cl2N5.HCl |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO |
| CAS号 | 899507-36-9 |
| 参考文献 | Donnelly-Roberts and Jarvis (2007) Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br.J.Pharmacol. 151 571. PMID: 17471177. McGaraughtyet al (2007) P2X7-related modulation of pathological nociception in rats. Neuroscience 146 1817. PMID: 17478048. Nelsonet al (2006) Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J.Med.Chem. 49 3659. PMID: 16759108. |