CBL0137
货号：
19110-10mg 基本售价：
10472.0 元 规格：
10 mg
产品信息
概述| 货号 | 19110-10mg |
| 描述 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.1 It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death.1 CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Item No. 11690) in preclinical models of pancreatic cancer.1,2 |
| 别名 | CBLC137;Curaxin 137; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gasparian, A.V.,Burkhart, C.A.,Purmal, A.A., et al. Curaxins: Anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci.Transl.Med. 3(95), (2011).
2.Burkhart, C.,Fleyshman, D.,Kohrn, R., et al. Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Oncotarget 5(22), 11038-11053 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 336.4 |
| 分子式 | C21H24N2O2 |
| CAS号 | 1197996-80-7 |
| 稳定性 | ≥ 2 years |
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