| 货号 | 17617-5mg |
| 描述 | Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1 Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated roles in vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2 NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery (KDs = 0.26 and 0.11 nM, respectively), eliciting endothelium-independent vasoconstriction.3 NMU-25 also suppresses glucose-stimulated insulin secretion in human islets, and this effect is lost in NMU R165W mutants, resulting in early-onset obesity.4 |
| 别名 | NMU-25; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mitchell, J.D.,Maguire, J.J., and Davenport, A.P. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. British Journal of Pharmacology 158, 87-103 (2009). 2.Greenwood, H.C.,Bloom, S.R., and Murphy, K.G. Peptides and their potential role in the treatment of diabetes and obesity. Rev.Diabet.Stud. 8(3), 355-368 (2011). 3.Mitchell, J.D.,Maguire, J.J.,Kuc, R.E., et al. Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system. Cardiovascular Research 81, 353-361 (2009). 4.Alfa, R.W.,Park, S.,Skelly, K.R., et al. Suppression of insulin production and secretion by a decretin hormone. Cell Metabolism 21(2), 323-333 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 3080.4 |
| 分子式 | C141H203N41O38 |
| CAS号 | 312306-89-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |