| 货号 | 14996-5mg |
| 描述 | STA-21 is a natural antibiotic that potently inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM.1 It blocks the growth and survival of cancer cells that express constitutively active STAT3 (e.g., DU145 cells, IC50 = 12.2 μM).1,2,3 STAT3 inhibitors, including STA-21, prevent the proliferation of human keratinocytes and have value in improving psoriasis.4 |
| 别名 | Ochromycinone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Song, H.,Wang, R.,Wang, S., et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America 102(13), 4700-4705 (2005). 2.Bhasin, D.,Cisek, K.,Pandharkar, T., et al. Design, synthesis, and studies of small molecule STAT3 inhibitors. Bioorganic & Medicinal Chemistry Letters 18(1), 391-395 (2008). 3.Chen, C.L.,Loy, A.,Cen, L., et al. Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. BMC Cancer 7, 111 (2007). 4.Miyoshi, K.,Takaishi, M.,Nakajima, K., et al. Stat3 as a therapeutic target for the treatment of psoriasis: A clinical feasibility study with STA-21, a Stat3 inhibitor. Journal of Investigative Dermatology 131(1), 108-117 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 306.3 |
| 分子式 | C19H14O4 |
| CAS号 | 28882-53-3 |
| 稳定性 | ≥ 2 years |
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