SI-2 hydrochloride ( )
货号：
5964/50 基本售价：
10340.8 元 规格：
50 mg
产品信息
概述| 货号 | 5964/50 |
| 别名 | 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available. |
| 运输条件 | Ambient |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 301.78 |
| 分子式 | C15H15N5.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 20 mM in DMSO |
| 参考文献 | Songet al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970. PMID: 27084884. |
