| 货号 | 15868-250mg |
| 描述 | Ivabradine is a highly selective open channel blocker that targets the mixed Na+/K+ inward “funny current” (If) carried by hyperpolarization-activated cyclic nucleotide gated (HCN) channels.1,2 It suppresses channel activity at HCN1, HCN2, and HCN4, all with the same EC50 value of 4 µM.3 Notably, ivabradine selectively targets cardiac signaling, resulting in resting heart rate reducing (bradycardic) effects.4,2 |
| 别名 | S 16257; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Thollon, C.,Cambarrat, C.,Vian, J., et al. Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: Comparison with UL-FS 49. British Journal of Pharmacology 112(1), 37-42 (1994). 2.Reil, J.C. and Böhm, M. Heart rate and heart failure: The role of ivabradine therapy. Curr.Opin.Cardiol. 28(3), 326-331 (2013). 3.Melchiorre, M.,Del Lungo, M.,Guandalini, L., et al. Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. Journal of Medicinal Chemistry 53(18), 6773-6777 (2010). 4.Ragueneau, I.,Laveille, C.,Jochemsen, R., et al. Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers. Clinical Pharmacology and Therapeutics 64(2), 192-203 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 505.1 |
| 分子式 | C27H36N2O5 • HCl |
| CAS号 | 148849-67-6 |
| 稳定性 | ≥ 2 years |
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