BMS-911543
货号：
21088-25mg 基本售价：
10290.0 元 规格：
25 mg
产品信息
概述| 货号 | 21088-25mg |
| 描述 | BMS-911543 is a potent, selective ATP-competitive inhibitor of Janus kinase 2 (JAK2) that exhibits IC50 values of 1, 356, 73, and 66 nM for JAK2, JAK1, JAK3, and TYK2, respectively.1 It exhibits antiproliferative activity in a variety of cell lines engineered to express the JAK2V617F activating mutation (IC50s = 60-70 nM).1,2 BMS-911543 exhibited limited activity in a mouse model of JAK2V617F-driven myeloproliferative neoplasm.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Purandare, A.V.,McDevitt, T.M.,Wan, H.Y., D., et al. Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2. Leukemia 26(2), 280-288 (2012).
2.Wan, H.,Schroeder, G.M.,Hart, A.C., et al. Discovery of a highly selective JAK2 inhibitor, BMS-911543, for the treatment of myeloproliferative neoplasms. ACS Med. Chem. Lett. 6(8), 850-855 (2015).
3.Pomicter, A.D.,Eiring, A.M.,Senina, A.V., et al. Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm. Exp. Hematol. 43(7), 537-545 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 432.5 |
| 分子式 | C23H28N8O |
| CAS号 | 1271022-90-2 |
| 稳定性 | ≥ 2 years |
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