| 货号 | 17359-5mg |
| 描述 | Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2.1,2 It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 µM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits.3,4,5 At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.2 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fujisawa, N.,Hayashi, S.,Kurdowska, A., et al. Inhibition of GROα-induced human endothelial cell proliferation by the α-chemokine inhibitor antileukinate. Cytokine 11(3), 231-238 (1999). 2.Bhatia, M., and Hegde, A. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regulatory Peptides 138(1), 40-48 (2007). 3.Hirayama, S.,Shiraishi, T.,Shirakusa, T., et al. Prevention of neutrophil migration ameliorates rat lung allograft rejection. Molecular Medicine 12(9-10), 208-213 (2006). 4.Hayashi, S.,Kurdowska, A.,Cohen, A.B., et al. A synthetic peptide inhibitor for α-chemokines inhibits the growth of melanoma cell lines. Journal of Clinical Investigation 99(11), 2581-2587 (1997). 5.Hayashi, S.,Kurdowska, A.,Miller, E.J., et al. Synthetic hexa- and heptapeptides that inhibit IL-8 from binding to and activating human blood neutrophils. Journal of Immunology 154(2), 814-824 (1995). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1003.2 |
| 分子式 | C45H66N18O7S |
| CAS号 | 138559-60-1 |
| 稳定性 | ≥ 2 years |
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