| 货号 | 16108-50mg |
| 描述 | ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) that less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors.1,2 In wild type mice, it mimics deletion of EP4 by producing severe colitis, with epithelial loss, crypt damage, and inflammation, after treatment with 3% dextran sodium sulfate.1 ONO-AE3-208 has also been used to implicate EP4 signaling in immune and autoimmune responses, inflammation, and cancer.3,4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kabashima, K.,Saji, T.,Murata, T., et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. Journal of Clinical Investigation 109(7), 883-893 (2002). 2.Jones, R.L.,Giembycz, M.A. and Woodward, D.F. Prostanoid receptor antagonists: Development strategies and therapeutic applications. British Journal of Pharmacology 158(1), 104-145 (2009). 3.Ma, X.,Kundu, N.,Rifat, S., et al. Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. Cancer Research 66(6), 2923-2927 (2006). 4.Kabashima, K.,Sakata, D.,Nagamachi, M., et al. Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nature Medicine 9(6), 744-749 (2003). 5.Esaki, Y.,Li, Y.,Sakata, D., et al. Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America 107(27), 12233-12238 (2010). 6.Komatsu, H.,Enjouji, S.,Ito, A., et al. Prostaglandin E2 inhibits proteinase-activated receptor 2-signal transduction through regulation of receptor internalization. Journal of Veterinary Medical Science 75(3), 255-261 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 426.4 |
| 分子式 | C24H21FN2O3 • Na |
| 稳定性 | ≥ 2 years |
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