| 货号 | 13523-25mg |
| 描述 | The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM (the EC50 values for apelin-17 and apelin-36 are 2.5 and 20 nM, respectively).1,2 It acts primarily in the periphery and central nervous system, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity.3 Unlike apelin-36, apelin-13 poorly blocks the entry of human immunodeficiency virus into cells.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tatemoto, K.,Hosoya, M.,Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251, 471-476 (1998). 2.Lee, D.K.,Cheng, R.,Nguyen, T., et al. Characterization of apelin, the ligand for the APJ receptor. Journal of Neurochemistry 74, 34-41 (2000). 3.Kleinz, M.J., and Davenport, A.P. Emerging roles or apelin in biology and medicine. Pharmacology & Therapeutics 107, 198-211 (2005). 4.Zou, M.X.,Liu, H.Y.,Haraguchi, Y., et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Letters 473, 15-18 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1550.8 |
| 分子式 | C69H111N23O16S |
| CAS号 | 217082-58-1 |
| 稳定性 | ≥ 2 years |
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