| 货号 | 11499-50mg |
| 描述 | Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM).1 It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.2,3 Obstoclax also induces autophagy in mouse embryo fibroblasts and in HeLa cells.4 This compound inhibits the growth of cancer cell lines and primary cancer isolates.3,2 |
| 别名 | GX15-070; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shore, G.C. and Viallet, J. Modulating the Bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer. Hematology Am.Soc.Hematol.Educ.Program 2005, 226-230 (2005). 2.Konopleva, M.,Watt, J.,Contractor, R., et al. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax). Cancer Research 68(9), 3413-3420 (2008). 3.Trudel, S.,Li, Z.H.,Rauw, J., et al. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood 109, 5430-5438 (2007). 4.Andreu-Fernández, V.,Genovés, A.,Messeguer, A., et al. BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components. PLoS One 8(2), e56881 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 413.5 |
| 分子式 | C20H19N3O • CH3SO3H |
| CAS号 | 803712-79-0 |
| 稳定性 | ≥ 2 years |
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