| 货号 | 1511/50 |
| 别名 | 1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective β3 adrenoceptor antagonist (IC50 values are 40, 408 and 648 nM for β3,β1andβ2 receptors respectively). Orally active in vivo. Also available as part of the β-Adrenoceptor Antagonist Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 361.91 |
| 分子式 | C21H27NO2.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in DMSO |
| CAS号 | 174689-39-5 |
| 参考文献 | Mizunoet al (2002) Stimulation of β3-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes. Br.J.Pharmacol. 135 951. PMID: 11861323. Manaraet al (1996) Functional identification of rat atypical β-adrenoceptors by the first β3-selective antagonists, aryloxypropanolaminotetralins. Br.J.Pharmacol. 117 435. PMID: 8821531. Manaraet al (1995) Aryloxypropanolaminotetralins are the first selective antagonists for atypical (β3) β-adrenoceptors. Pharmacol.Comm. 6253. |