SEA0400
货号：
19876-50mg 基本售价：
10234.0 元 规格：
50 mg
产品信息
概述| 货号 | 19876-50mg |
| 描述 | SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).1 It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinsons disease and to attenuate reperfusion injury in both in vitroandin vivo cerebral ischemic models.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Matsuda, T.,Arakawa, N.,Takuma, K., et al. SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J.Pharmacol.Exp.Ther. 298(1), 249-256 (2001).
2.Nashida, T.,Takuma, K.,Fukuda, S., et al. The specific Na+/Ca2+ exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem.Int. 59(1), 51-58 (2011).
3.Ago, Y.,Kawasaki, T.,Nashida, T., et al. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease. Neuropharmacology 61(8), 1441-1451 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 371.4 |
| 分子式 | C21H19F2NO3 |
| CAS号 | 223104-29-8 |
| 稳定性 | ≥ 2 years |
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