NCT-501 (hydrochloride)
货号：
18319-25mg 基本售价：
10234.0 元 规格：
25 mg
产品信息
概述| 货号 | 18319-25mg |
| 描述 | Aldehyde dehydrogenases (ALDHs) catalyze the NAD(P)+-dependent oxidation of aldehyde-containing substrates to the corresponding carboxylic acids.1 ALDH1A1 activity is elevated in certain stem cells and cancers.1 NCT-501 is a potent, reversible, theophylline-based inhibitor of ALDH1A1 (IC50 = 40 nM for the human form).2 It is selective for ALDH1A1 over other ALDH isozymes as well as other dehydrogenases. Pharmacokinetic studies indicate that NCT-501 has high bioavailability when delivered intraperitoneally, with rapid phase I modification in the liver.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tomita, H.,Tanaka, K.,Tanaka, T., et al. Aldehyde dehydrogenase 1A1 in stem cells and cancer. Oncotarget 1.15.16, (2016).
2.Yang, S.M.,Yasgar, A.,Miller, B., et al. Discovery of NCT-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1). Journal of Medicinal Chemistry 58, 5967-5978 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 453 |
| 分子式 | C21H32N6O3 • HCl |
| 稳定性 | ≥ 2 years |
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