| 货号 | 1379/50 |
| 别名 | 2,3-Dihydro-5-(methylthio)-N-3-pyri |
| 供应商 | Tocris |
| 生物活性 | Potent, selective 5-HT2C/2B receptor antagonist. pKi values are 6.4, 7.9 and 8.6 for 5-HT2A,2Band2C receptors respectively. Centrally active upon systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 353.36 |
| 分子式 | C16H14F3N3OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 196965-14-7 |
| 参考文献 | Bristowet al (2000) Evidence for accelerated desensitisation of 5-HT2C receptors following combined treatment with fluoxetine and the 5-HT1A receptor antagonist, WAY 100,635, in the rat. Neuropharmacology 39 1222. PMID: 10760364. Hutsonet al (2000) Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT2C/2B receptor antagonists: neurochemical and behavioural studies. Neuropharmacology 39 2318. PMID: 10974315. Bromidgeet al (1998) Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines. J.Med.Chem. 41 1598. PMID: 9572885. |