| 货号 | 1497/50 |
| 别名 | 9-[3-(cis-3,5-Dimethyl-1-piperaziny |
| 供应商 | Tocris |
| 生物活性 | Antagonist at σ receptors (IC50 values are 1480 and 386 nM at σ1andσ2 receptors respectively). Also binds to the dopamine transporter (IC50 = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 394.39 |
| 分子式 | C21H27N3.2HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water |
| CAS号 | 75859-03-9 |
| 参考文献 | Matsumotoet al (2001) Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. Neuropharmacology 41 878. PMID: 11684152. Husbandset al (1997) Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the dopamine transporter. J.Med.Chem. 40 4340. PMID: 9435903. Ferriset al (1986) Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci. 38 2329. PMID: 2873494. |