nTZDpa (50 MG)
货号：
2150/50 基本售价：
10192.1 元 规格：
50 mg
产品信息
概述| 货号 | 2150/50 |
| 别名 | 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid |
性能| 供应商 | Tocris |
| 生物活性 | Potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC50 ~ 285 nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 428.33 |
| 分子式 | C22H15Cl2NO2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 118414-59-8 |
| 参考文献 | Bergeret al (2003) Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator. Mol.Endocrinol. 17 662. PMID: 12554792. |
