LH 846 (50 MG)
货号：
4896/50 基本售价：
10192.1 元 规格：
50 mg
产品信息
概述| 货号 | 4896/50 |
| 别名 | N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide |
性能| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of casein kinase (CK) 1δ(IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ,εandα); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 316.81 |
| 分子式 | C16H13ClN2OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Leeet al (2011) A small molecule modulates circadian rhythms through phosphorylation of the period protein. Agnew Chem.Int.Ed.Engl. 50 10608. PMID: 21954091. |
