| 货号 | 3191/50 |
| 别名 | 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2 |
| 供应商 | Tocris |
| 生物活性 | GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC50 ~ 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 429.61 |
| 分子式 | C27H35N5 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 500579-04-4 |
| 参考文献 | Fuet al (2012) GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 330 22. PMID: 23200667. Mazumdaret al (2011) Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res. 71 5904. PMID: 21747117. Lauthet al (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small molecule antagonists. Proc.Natl.Acad.Sci.USA 104 8455. PMID: 17494766. |