| 货号 | 5281/50 |
| 别名 | N-Ethyl-7,8-dihydro-7-methyl-8-oxo- |
| 供应商 | Tocris |
| 生物活性 | Ligand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 401.46 |
| 分子式 | C23H23N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol with sonication |
| 参考文献 | Qiuet al (2013) Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Prog.Neuropsychopharmacol.Biol.Psychiatry 45 40. PMID: 23624119. Kitaet al (2004) Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br.J.Pharmacol. 142 1059. PMID: 15249420. |