TAS 120
货号：
21136-10mg 基本售价：
10192.0 元 规格：
10 mg
产品信息
概述| 货号 | 21136-10mg |
| 描述 | TAS 120 is an orally bioavailable inhibitor of fibroblast growth factor receptors (FGFRs) that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations.1 It prevents phosphorylation of FGFRs and impedes downstream signaling pathways in cells.1 TAS 120 blocks the proliferation of human cancer cell lines with FGFR gene abnormalities but does not alter the growth of cell lines with wild-type FGFR.1 It inhibits FGFR phosphorylation in tumors and tumor growth in human xenograft mouse models in a dose-dependent manner.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ochiiwa, H.,Fujita, H.,Itoh, K., et al. Abstract A270: TAS-120, a highly potent andselective irreversible FGFR inhibitor, is effective in tumors harboring various FGFR gene abnormalities. Mol. Cancer Ther. 12(11), (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 418.5 |
| 分子式 | C22H22N6O3 |
| CAS号 | 1448169-71-8 |
| 稳定性 | ≥ 2 years |
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