| 货号 | 10009995-250ug |
| 描述 | (±)9,10-EpOME-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-mass spectrometry (MS). (±)9(10)-EpOME (Item No. 52400) is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst.1 It has been recovered from the lungs of hyperoxic rats and from humans with acute respiratory distress syndrome.2 Mitochondrial dysfunction is the main feature of (±)9(10)-EpOME cytotoxicity, which may be due to the diol metabolites as well as the parent epoxide.3,4 |
| 别名 | (±)9,10-EODE-d4;Leukotoxin-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hayakawa, M.,Sugiyama, S.,Takamura, T., et al. Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenoate. Biochemical and Biophysical Research Communications 137, 424-430 (1986). 2.Ozawa, T.,Hayakawa, M.,Takamura, T., et al. Biosynthesis of leukotoxin, 9,10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia. Biochemical and Biophysical Research Communications 134, 1071-1078 (1986). 3.Kosaka, K.,Suzuki, K.,Hayakawa, M., et al. Leukotoxin, a linoleate epoxide: Its implication in the late death of patients with extensive burns. Molecular and Cellular Biochemistry 139, 141-148 (1994). 4.Moran, J.H.,Weise, R.,Schnellmann, R.G., et al. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. Toxicology and Applied Pharmacology 146, 53-59 (1997). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 300.5 |
| 分子式 | C18H28D4O3 |
| 稳定性 | ≥ 1 year |
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