4-hydroxy Nonenal Mercapturic Acid-d3
货号：
9000348-500ug 基本售价：
10010.0 元 规格：
500 ug
产品信息
概述| 货号 | 9000348-500ug |
| 描述 | 4-hydroxy Nonenal mercapturic acid-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE mercapturic acid by GC- or LC-mass spectrometry. Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat.1 About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates.2 The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form γ-lactols and γ-lactones, respectively, producing at least four or five end urinary metabolites of 4-HNE in vivo. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Laurent, A.,Alary, J.,Debrauwer, L., et al. Analysis in the rat of 4-hydroxynonenal metabolites excreted in bile: Evidence of enterohepatic circulation of these byproducts of lipid peroxidation. Chemical Research in Toxicology 12, 887-894 (1999).
2.Alary, J.,Bravais, F.,Cravedi, J.P., et al. Mercapturic acid conjugates as urinary end metabolites of the lipid peroxidation product 4-hydroxy-2-nonenal in the rat. Chemical Research in Toxicology 8, 34-39 (1995).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥99% deuterated forms (d1-d3) |
| 计算分子量 | 322.4 |
| 分子式 | C14H22D3NO5S |
| 稳定性 | ≥ 1 year |
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